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CAMP responsive element modulator
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CAMP responsive element modulator : ウィキペディア英語版
CAMP responsive element modulator

cAMP-responsive element modulator is a protein that in humans is encoded by the ''CREM'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1390 )
== Function ==

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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